Recently, the team of Professor Minlin Zhong from the School of Materials Science and Engineering of Tsinghua University used ultra-fast laser micro-nano manufacturing combined with chemical oxidation to prepare an ultra-sensitive surface-enhanced Raman scattering (SERS) substrate structure, achieving the world’s highest molar per liter (10-18mol). /L) Detection limit.

SERS is a phenomenon in which the Raman scattering signal of adsorbed molecules is greatly enhanced by the near-field local enhancement of the special nanostructures on the metal surface. It is a highly sensitive inspection method and can even realize single-molecule detection. It is widely used in molecular labeling. It is a high-throughput rapid detection method in the fields of immune detection, trace detection, cancer and virus detection, and in vivo detection.

The following is a schematic diagram of the ultrafast laser preparation of this SERS substrate: